Nanoanesthesia: a novel, intravenous approach to ankle block in the rat by magnet-directed concentration of ropivacaine-associated nanoparticles.
Identifieur interne : 001F61 ( Main/Exploration ); précédent : 001F60; suivant : 001F62Nanoanesthesia: a novel, intravenous approach to ankle block in the rat by magnet-directed concentration of ropivacaine-associated nanoparticles.
Auteurs : Venkat R R. Mantha [États-Unis] ; Harsha K. Nair ; Raman Venkataramanan ; Yuan Yue Gao ; Krzysztof Matyjaszewski ; Hongchen Dong ; Wenwen Li ; Doug Landsittel ; Elan Cohen ; William R. LariviereSource :
- Anesthesia and analgesia [ 1526-7598 ] ; 2014.
Descripteurs français
- KwdFr :
- Aire sous la courbe, Amides (administration et posologie), Amides (pharmacocinétique), Anesthésie (), Anesthésiques locaux (administration et posologie), Anesthésiques locaux (pharmacocinétique), Animaux, Bloc nerveux (), Magnétisme, Membre pelvien, Mâle, Nanoparticules, Préparation de médicament, Période, Rat Sprague-Dawley, Rats.
- MESH :
- administration et posologie : Amides, Anesthésiques locaux.
- pharmacocinétique : Amides, Anesthésiques locaux.
- Aire sous la courbe, Anesthésie, Animaux, Bloc nerveux, Magnétisme, Membre pelvien, Mâle, Nanoparticules, Préparation de médicament, Période, Rat Sprague-Dawley, Rats.
English descriptors
- KwdEn :
- Amides (administration & dosage), Amides (pharmacokinetics), Anesthesia (methods), Anesthetics, Local (administration & dosage), Anesthetics, Local (pharmacokinetics), Animals, Area Under Curve, Drug Compounding, Half-Life, Hindlimb, Magnetics, Male, Nanoparticles, Nerve Block (methods), Rats, Rats, Sprague-Dawley.
- MESH :
- chemical , administration & dosage : Amides, Anesthetics, Local.
- chemical , pharmacokinetics : Amides, Anesthetics, Local.
- methods : Anesthesia, Nerve Block.
- Animals, Area Under Curve, Drug Compounding, Half-Life, Hindlimb, Magnetics, Male, Nanoparticles, Rats, Rats, Sprague-Dawley.
Abstract
As an alternative to current methods of local nerve block, we studied the feasibility of producing ankle block in the rat with IV injection of magnetic nanoparticles (MNPs) associated with ropivacaine and application of a magnet at the ankle.
DOI: 10.1213/ANE.0000000000000175
PubMed: 24722259
Affiliations:
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Le document en format XML
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Mantha</name><affiliation wicri:level="2"><nlm:affiliation>From the *Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; †Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania; ‡Center for Macromolecular Engineering, Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania; §Data Center, Center for Research on Health Care, and ‖Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>From the *Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; †Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania; ‡Center for Macromolecular Engineering, Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania; §Data Center, Center for Research on Health Care, and ‖Department of Medicine, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Nair, Harsha K" sort="Nair, Harsha K" uniqKey="Nair H" first="Harsha K" last="Nair">Harsha K. 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Mantha</name><affiliation wicri:level="2"><nlm:affiliation>From the *Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; †Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania; ‡Center for Macromolecular Engineering, Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania; §Data Center, Center for Research on Health Care, and ‖Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>From the *Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; †Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania; ‡Center for Macromolecular Engineering, Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania; §Data Center, Center for Research on Health Care, and ‖Department of Medicine, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Nair, Harsha K" sort="Nair, Harsha K" uniqKey="Nair H" first="Harsha K" last="Nair">Harsha K. 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Lariviere</name><name sortKey="Li, Wenwen" sort="Li, Wenwen" uniqKey="Li W" first="Wenwen" last="Li">Wenwen Li</name><name sortKey="Matyjaszewski, Krzysztof" sort="Matyjaszewski, Krzysztof" uniqKey="Matyjaszewski K" first="Krzysztof" last="Matyjaszewski">Krzysztof Matyjaszewski</name><name sortKey="Nair, Harsha K" sort="Nair, Harsha K" uniqKey="Nair H" first="Harsha K" last="Nair">Harsha K. Nair</name><name sortKey="Venkataramanan, Raman" sort="Venkataramanan, Raman" uniqKey="Venkataramanan R" first="Raman" last="Venkataramanan">Raman Venkataramanan</name></noCountry><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Mantha, Venkat R R" sort="Mantha, Venkat R R" uniqKey="Mantha V" first="Venkat R R" last="Mantha">Venkat R R. Mantha</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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